Disintegrin and metalloproteinase domain-containing protein 17 is a protein in humans that is encoded by ADAM17 gene. Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

ADAM17 Antibodies

ADAM17 for Homo sapiens (Human)

产品货号 产品名称 种属反应性 应用类型
CSB-PA001277GA01HU ADAM17 Antibody Human ELISA,WB
CSB-PA050198 Cleaved-ADAM17 (R215) Antibody Human WB, ELISA
CSB-PA050199 Phospho-ADAM17 (T735) Antibody Human WB, IHC, ELISA
CSB-PA050200 ADAM17 Antibody Human IF, ELISA
CSB-PA261035 ADAM17 Antibody Human ELISA,IHC


ADAM17 cDNA for Homo sapiens (Human)

产品货号 产品名称 载体 登录号
CSB-CL001277HU1 ADAM17 pUC NM_003183.4


ADAM17 ELISA Kit for Homo sapiens (Human)

产品货号 产品名称 样本类型 灵敏度
CSB-E09315h 人肿瘤坏死因子α转化酶(TACE)ELISA Kit serum, plasma, tissue homogenates, cell lysates 15.6 pg/mL

ADAM17 ELISA Kit for Mus musculus (Mouse)

产品货号 产品名称 样本类型 灵敏度
CSB-EL001277MO Mouse Disintegrin and metalloproteinase domain-containing protein 17(ADAM17) ELISA kit serum, plasma, tissue homogenates 3.9 pg/mL