Apoptosis-inducing factor 1, mitochondrial is a protein in humans that is encoded by AIFM1 gene. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

AIFM1 Antibodies

AIFM1 for Homo sapiens (Human)

产品货号 产品名称 种属反应性 应用类型
CSB-PA001492GA01HU AIFM1 Antibody Human ELISA,WB,IHC
CSB-PA001492HA01HU AIFM1 Antibody Human ELISA, WB, IHC, IF
CSB-PA001492HB01HU AIFM1 Antibody, HRP conjugated Human ELISA
CSB-PA001492HC01HU AIFM1 Antibody, FITC conjugated Human ELISA
CSB-PA001492HD01HU AIFM1 Antibody, Biotin conjugated Human ELISA
CSB-PA000836 AIFM1 Antibody Human WB,IHC,IF,ELISA
CSB-PA068462 AIFM1 Antibody Human ELISA,WB,IHC
CSB-PA480938 AIFM1 Antibody Human ELISA,WB,IHC


AIFM1 cDNA for Rattus norvegicus (Rat)

产品货号 产品名称 载体 登录号
CSB-CL872890RA Aifm1 pUC NM_031356.1


AIFM1 ELISA Kit for Homo sapiens (Human)

产品货号 产品名称 样本类型 灵敏度
CSB-E09006h 人凋亡诱导因子(AIF)ELISA Kit serum, plasma, tissue homogenates, cell lysates 5.8 pg/mL